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Radiesse is a long lasting filler composed of smooth calcium hydroxylapatite particles similar to the compounds found in bones and teeth, and suspended in a gel. Once injected, Radiesse stimulates buildup of new collagen, and the results are estimated to last about two years. Radiesse is injected in small amounts deep under the skin to fill creases, lines and wrinkles, to soften Nasolabial folds and facial lines, add fullness to the skin and fill in scars.